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GnRH agonist

Leuprolide

Brand names: Lupron

Last reviewed 2026-08-01
Women-specific evidencePregnancy/lactation data limited

Leuprolide is an established GnRH agonist used in several women's health conditions. Use in pregnancy is contraindicated and bone-health effects require monitoring.

Key takeaways

  • Approved for endometriosis, uterine fibroids, and other hormone-dependent conditions.
  • Pregnancy is a contraindication; counseling should follow current label.
  • Bone-density effects are relevant to long-term use in women.

Mechanism and pathway

Initially stimulates then downregulates GnRH receptors, suppressing sex steroid production.

Peptide relationship: Leuprolide is a synthetic GnRH decapeptide analog.

Route and formulation: Intramuscular, Subcutaneous

Author

Ian Gauntt

RN, BSN — 10 years as a critical care nurse

Medical reviewer

Medical Reviewer (Pending Assignment)

Medical review pending assignment by a licensed clinician.

Last reviewed 2026-08-01Next review 2026-11-01

Medical disclaimer: Her Health Peptides publishes educational, source-linked summaries. We do not provide individualized medical advice, diagnosis, or treatment recommendations. Always talk with a licensed clinician about your specific situation, especially if you are pregnant, breastfeeding, planning pregnancy, or taking other medicines.

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